Mrc2 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comMrc2 Polyclonal Antibody for Mouse(Mus musculus)

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Mrc2 (Gene name),

C-type mannose receptor 2 (Protein name ), MRC2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Mrc2(Kiaa0709);

Protein name:

C-type mannose receptor 2;

Alternative:

Macrophage mannose receptor 2;Lectin lambda;

CD:

CD280;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts directly with PLAUR/UPAR and PLAU/pro-UPA to form a tri-molecular complex. Interacts with collagen V and with C-terminal region of type I collagen/COL1A1.

Function:

May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May participate in remodeling of extracellular matrix co-operating with the matrix metalloproteinases (MMPs).

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

1479

Sequence:

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1400:

1450:

1479:

YSRSSHSGPA | EATEKNILVS | DMEMNEQQE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q64449

UniGene:

Mm.235616

SMR:

Q64449

Pfam:

PF00040

KEGG:

mmu:17534

Uniprot:

Q64449

FOR

ELISA Kit for Mouse C-type mannose receptor 2

Cat.:

E2105h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Mouse C-type mannose receptor 2

Cat.:

E2105m

Price:

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MSDS:

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Packing:

96T

ELISA Kit for Mouse C-type mannose receptor 2

Cat.:

E2105r

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Packing:

96T

CLIA Kit for Mouse C-type mannose receptor 2

Cat.:

U2105r

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MSDS:

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Packing:

96T

CLIA Kit for Mouse C-type mannose receptor 2

Cat.:

U2105m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse C-type mannose receptor 2

Cat.:

U2105h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse C-type mannose receptor 2

Cat.:

P2105Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse C-type mannose receptor 2

Cat.:

P2105Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse C-type mannose receptor 2

Cat.:

P2105Rb-r

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse C-type mannose receptor 2

Protein for Mouse C-type mannose receptor 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Characterization of a novel member of the macrophage mannose receptor type C lectin family."
Wu K. , Yuan J. , Lasky L.A.
J. Biol. Chem.271:21323-21330(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain: C57BL/6J.
tissue: Oviduct.
3.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
4.

"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Koseki H. , Hiraoka S. , Saga Y. , Nagase T. , Ohara O. , Koga H.
DNA Res.10:167-180(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 479-1479 (ISOFORM 1)
tissue: Embryonic tail.
5.

"A targeted deletion in the endocytic receptor gene Endo180 results in a defect in collagen uptake."
East L. , McCarthy A. , Wienke D. , Sturge J. , Ashworth A. , Isacke C.M.
EMBO Rep.4:710-716(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
6.

"uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion."
Engelholm L.H. , List K. , Netzel-Arnett S. , Cukierman E. , Mitola D.J. , Aaronson H. , Kjoller L. , Larsen J.K. , Yamada K.M. , Strickland D.K. , Holmbeck K. , Danoe K. , Birkedal-Hansen H. , Behrendt N. , Bugge T.H.
J. Cell Biol.160:1009-1015(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
7.

"uPARAP/endo180 directs lysosomal delivery and degradation of collagen IV."
Kjoller L. , Engelholm L.H. , Hoyer-Hansen M. , Danoe K. , Bugge T.H. , Behrendt N.
Exp. Cell Res.293:106-116(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
8.

"Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy."
Curino A.C. , Engelholm L.H. , Yamada S.S. , Holmbeck K. , Lund L.R. , Molinolo A.A. , Behrendt N. , Nielsen B.S. , Bugge T.H.
J. Cell Biol.169:977-985(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
9.

"The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
Gundry R.L. , Raginski K. , Tarasova Y. , Tchernyshyov I. , Bausch-Fluck D. , Elliott S.T. , Boheler K.R. , Van Eyk J.E. , Wollscheid B.
Mol. Cell. Proteomics8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-139 AND ASN-363
tissue: Myoblast.
10.

"Three-dimensional interplay among the ligand-binding domains of the urokinase-plasminogen-activator-receptor-associated protein, Endo180."
Rivera-Calzada A. , Robertson D. , MacFadyen J.R. , Boskovic J. , Isacke C.M. , Llorca O.
EMBO Rep.4:807-812(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY ELECTRON MICROSCOPY (18 ANGSTROMS)

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